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近期美国TRENDS IN PHARMACOLOGICAL SCIENCES，发表题为Introducing the Microbiome into Precision Medicine文章，认为是时候将微生物组引入到精准医学中了。

  ① 美国精准医学计划为研究者和临床专业人士的合作打下坚实基础，这将推动新一代技术的研发，帮助病人治疗和康复，增加有效预先干预的机会；② 微生物组在健康和疾病中扮演着极为重要的角色，影响内分泌、生理甚至神经系统，改变许多疾病的治疗效果，并影响药物反应和耐受性；③ 本文总结微生物组对精准健康计划的影响，并列举了一些很好的例子，说明精准微生物组健康干预如何实施；④ 简要介绍微生物组分析技术、疗法和药物监管和应用等内容。

  Title：

  Introducing the Microbiome into Precision Medicine

  DOI：

  10.1016/j.tips.2016.10.001

  Abstract：

  Understanding how individual people respond to medical therapy is a key facet of improving the odds ratio that interventions will have a positive impact. Reducing the non-responder rate for an intervention or reducing complications associated with a particular treatment or surgery is the next stage of medical advance. The Precision Medicine Initiative, launched in January 2015, set the stage for enhanced collaboration between researchers and medical professionals to develop next-generation techniques to aid patient treatment and recovery, and increased the opportunities for impactful pre-emptive care. The microbiome plays a crucial role in health and disease, as it influences endocrinology, physiology, and even neurology, altering the outcome of many different disease states, and it augments drug responses and tolerance. We review the implications of the microbiome on precision health initiatives and highlight excellent examples, whereby precision microbiome health has been implemented.

  All Authors：

  Thomas M Kuntz,Gilbert Jack

  First Authors：

  Thomas M Kuntz

  Correspondence：

    Jack A Gilbert

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                                                           来源：搜狐健康网